Cell Physiol Biochem 43:69РІР‚вЂњ81Р”Р„min FU, Hoshiar AK, Do TD, Noh Y, Shah SA, Khan MS, Yoon J, Kim MO (2017) Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of AlzheimerРІР‚в„ўs disease. Wang M, Li Y, Ni C, Song G (2017) Honokiol attenuates oligomeric amyloid beta1-42-induced AlzheimerРІР‚в„ўs disease in mice through attenuating mitochondrial apoptosis and inhibiting the nuclear factor Kappa-B signaling pathway. Thal DR, Capetillo-Zarate E, Del Tredici K, Braak H (2006) The development of amyloid beta protein deposits in the aged brain. TREM2 can serve as a potential therapeutic target for treating systemic inflammation in AD progression. Collectively, we conclude that an imbalance of TLR4/TREM2 may be a potential link between AD and systemic inflammation. Further, Morris water maze (MWM) testing data indicated that LPS administration acutely aggravated cognitive impairment in APP/PS1 mice, suggesting that the addition of systemic inflammation can potentially accelerate the progression of AD. Similar alterations were observed in our in vitro experiment with РћР†-amyloid 1РІР‚вЂњ42 (AРћР† 1РІР‚вЂњ42)-treated N9 microglia. This imbalance of TLR4/TREM2 contributed to microglial over-activation, followed by increased neuronal apoptosis in the cortex of APP/PS1 mice these changes did not alter the expression level of AРћР† 1РІв‚¬вЂ™42. Interestingly, after LPS treatment, TLR4 expression was persistently up-regulated, while TREM2 expression was significantly down-regulated in APP/PS1 mice, suggesting that the negative regulatory effect of TREM2 on inflammation might be suppressed by LPS-induced hyperactive TLR4. Initial results from the cortex showed that compared with wild-type mice, APP/PS1 mice exhibited elevated gene and protein expression levels of both TLR4 and TREM2 with different degree. In this study, intraperitoneal injection of lipopolysaccharide (LPS) into APP/PS1 transgenic AD model was used to mimic systemic inflammation in the development of AD. Microglial toll-like receptor 4 (TLR4) and triggering receptor expressed on myeloid cells 2 (TREM2) are two key regulators of inflammation that may play an essential role in this complex pathophysiological process. However, the related molecular mechanisms remain poorly understood. Please be wary of anyone contacting you without an email address ending in When in doubt, contact us 1-88.Clinically, superimposed systemic inflammation generally has significant deleterious effects on the AlzheimerРІР‚в„ўs disease (AD) progression. LP is committed to a safe and efficient recruitment process. If requested prior to your start date, please be sure it is coming from someone at LP. It is generally done in-person on your first day. While new hire paperwork does include the collection of some personal information for background checks and optional direct deposit set up, this information will never be requested by anyone not using an email address.If itРІР‚в„ўs determined that you are the best person for the role, you will be notified by your LP point of contact and/or hiring manager.This recruiter will be your point of contact throughout the interview process.If we believe you are, you will be contacted by a recruiter or HR representative that has an email address ending in If you hear from anyone without this email address, please be advised it is not from us.Once youРІР‚в„ўve applied for a position, we will evaluate your skills and expertise to see if you are a good match for the role.When you apply for a position at LP, hereРІР‚в„ўs what you can expect: Our commitment to people starts with the recruitment process, which we strive to make as easy and efficient as possible. People are LPРІР‚в„ўs most important asset and finding the right people for the right job is critical to our success.

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